医疗特长（限400字内）：

1.    从事普通外科专业30余年，长期致力于胃癌外科研究，率先在国内开展和推广胃癌标准D2和D2(+)淋巴结清扫、鞘内淋巴结清扫,进展期胃癌外科治疗后5年生存率超过60%,治疗效果达到国际先进水平;

2． 擅长胃肠间质瘤(GIST)外科和综合治疗；擅长结直肠肿瘤、结直肠息肉及息肉病、炎症性肠病及肛门良性疾病的诊治，对于全直肠系膜切除、低位保功能的直肠癌手术、全结肠切除术、结肠“J” 型贮袋重建直肠术等方面有深入研究和丰富经验。

3． 对于胰腺疾病、腹膜后肿瘤、食道癌、食道良性疾病等有丰富的诊治经验，尤其在胃或结肠代食道术、保留幽门的Whipple术、消化道重建术等方面在国内属于领先水平;

4．熟练应用达芬奇机器人、腹腔镜及消化道内镜对胃肠道疾病进行诊断和治疗。

 

研究方向：

胃癌外科治疗；胃癌淋巴结转移机制和防治的研究；胃肠间质瘤（GIST）外科治和综合治疗及基础临床研究；遗传性胃肠道疾病的研究；结直肠癌的早期诊断和外科治疗；临床营养；胰腺疾病的诊治与基础研究；快速康复外科。

 

主要教育和工作经历：

1984.7                  毕业于中山医科大学留校工作

1996.6-1996.12     香港大学进修

2001.1-2002.12     美国Utah大学  博士后

1997.12-2003.12   中山医科大学附属第一医院外科副教授、副主任医师

2003.12-至今        中山大学附属第一医院外科教授、主任医师

2003.5-2005.8       中山大学附属第一医院院长办公室副主任

2005.9-2014.4       中山大学附属第一医院胃肠胰专科主任

2005.9-至今          中山大学附属第一医院外科主任

2008.7-至今          中山大学胃癌诊治研究中心主任

2011.8-至今          中山大学附属第一医院院长助理

2014.4-至今          中山大学附属第一医院胃肠外科中心主任 

社会兼职：

1. 现任亚洲外科学会会员，中华医学会外科学分会委员，中华医学会外科学分会胃肠外科学组副组长，中国医师协会外科医师分会上消化道外科医师委员会副主任委员兼秘书长，中国抗癌协会胃癌专业委员会副主任委员，中国临床肿瘤学会（CSCO）胃肠间质瘤专家委员会副组长，中国医师协会第二届医学教育委员会委员;

2. 广东省医学会胃肠外科学分会主任委员，广东省健康管理学会胃肠病学专业委员会主任委员，广东省医疗行业协会消化外科管理分会主任委员，广东省医学会第七届理事会理事，广东省抗癌协会第三届理事会常务理事，广东省抗癌协会胃癌专业委员会副主委，广东省抗癌协会胰腺癌专业委员会副主任，广东省抗癌协会大肠癌专业委员会常委，广东省医学会外科学分会第八届委员会常委，国家和广东省自然科学基金评委，中华医学科技奖评委，广东省科技奖评委

3.《消化肿瘤杂志》(电子版)主编、《中华胃肠外科杂志》副主编、《中华普通外科文献》编辑部副主任、Annals of Surgery、Journal of Surgical Oncology、《中华外科杂志》、《中国实用外科杂志》、《中华普通外科杂志》等10余种杂志编委。

 

论著：在Cancer Research, International Journal of Cancer, Cancer Letters, Annals Surgical Oncology等杂志发表论文350余篇。

1. CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer. Cancer Letters 2015，359（2）：335-343

2. Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients. Journal of Cancer Research and Clinical Oncology 2015,141（3）：443-452

3. Refractory left pleural effusion in an older patient: Atypical presentation of colorectal carcinoma. Oncology Letters  2015，9（3）：1055-1058

4. Uncontrolled inflammation induced by AEG-1 promotes gastric cancer and is associated with poor prognosis, Cancer Res 2014 Oct 1;74(19):5541-52.

5. Systematic review of nasogastric or nasojejunal decompression after gastrectomy for gastric cancer. European Journal of Surgical Oncology 2014，40（12）：1763-1770

6. The prognostic significance of the prognostic nutritional index in cancer: a systematic review and meta-analysis. Journal of Cancer Research and Clinical Oncology 2014，140（9）：1537-1549

7. RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer. World Journal of Gastroenterology 2014，20（29）：10094-10107

8. Impact of Pre-existing Type-2 Diabetes on Patient Outcomes After Radical Resection for Gastric Cancer: A Retrospective Cohort Study. Dig Dis Sci 2014 May;59(5):1017-24.

9. Efficacy and complications of polyethylene glycols for treatment of constipation in children: a meta-analysis.，Medicine (Baltimore) 2014，93（16）：e65-e65

10.Clinicopathological features and trend changes of gastric carcinoma in Southern China. World J Gastroenterol. 2014 Apr 21;20(15)

11.Rare case of an abdominal mass: Reactive nodular fibrous pseudotumor of the stomach encroaching on multiple abdominal organs. World J Clin Cases. 2014 Apr 16;2(4):111-9.

12.Evaluation of para-aortic nodal dissection for locoregionally advanced gastric cancer with 1–3 involved para-aortic nodes. Chin Med J. 2014,127(3):435-441

13.Evaluation of Skeletonization of the Hepatoduodenal Ligament for the Lower Third Gastric Cancer by Propensity Score Analysis. Hepatogastroenterology. 2013 Oct;60(127):1789-96

14.Efficacy of adjuvant XELOX and FOLFOX6 chemotherapy after D2 dissection for gastric cancer. World J Gastroenterol. 2013 Jun 7;19(21):3309-15.

15.High-expression of DJ-1 and Loss of PTEN Associated with Tumor Metastasis and Correlated with Poor Prognosis of Gastric Carcinoma. Int J Med Sci. 2013 Sep 24;10(12):1689-97.

16.Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma. Eur J Surg Oncol. 2013 Feb;39(2):141-9

17.Fast-Track Surgery Improves Postoperative Clinical Recovery and Immunity After Elective Surgery for Colorectal Carcinoma:Randomized Controlled Clinical Trial. World Journal of Surgery. 2012; 36(8):1874-1880.

18.Risk factors for adverse outcome in low rectal cancer. WJG.2012;1(1):64-69.

19.Fast track surgery accelerates the recovery of postoperative insulin sensitivity. Chinese Medical Journal. 2012;9,125(18):3261-3265.

20.Use of absorbable hemostatic gauze with medical adhesive is effective for achieving hemostasis in presacral hemorrhage. Am J Surg. 2012 Apr;203(4):5-8.

21.High CpG island methylator phenotype is associated with lymph node metastasis and prognosis in gastric cancer. Cancer Sci.2012 Jan; 103(1):73-79.

22.Lymphatic endothelial cell-secreted CXCL1 stimulates lymphangiogenesis and metastasis of gastriccancer. Int J Cancer.2012.Feb 15;130(4):787-797.

23.Tumor-associated macrophages promote angiogenesis and lymphangiogenesis of gastric cancer. J Surg Oncol.2012 Sep 15;106(4):462-468.

24.Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy. Diagnostic Pathology. 2012,7:163.

25.Abnormal expression of E-cadherin in tumor cells is associated with poor prognosis of gastric carcinoma. J Surg Oncol. 2012 Sep 1;106(3):304-10.

26.-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer. World Journal of Gastroenterology.2011 May 14;17(18):2315-2325.

27. Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol. 2011; 28(2): 455-462.

28.High Expression of PRL-3 can Promote Growth of Gastric Cancer and Exhibits a Poor Prognostic Impact on Patients. Ann Surg Oncol. 2009,1,16(1):208-219.

29.Effect of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients. Chinese Medical Journal.2010;123(21):3084-3088.

30.Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China. Chinese Medical Journal. 2009,7,122(13):1486-1491.

31.Early operation for fulminant acute pancreatitis:a possible way to decrease mortality. Chinese Medical Journal. 2009,7,122(13):1492-1494.

32.Elevated PRL-3 expression was more frequently detected in the large primary gastric cancer and exhibits a poor prognostic impact on the patients. J Cancer Res Clin Oncol. 2009 Aug; 135(8):1041-1046.

33.Comparison of patients by family history with gastric and non-gastric cancer. World J Gastroenterol. 2009,15(21):2644-2650.

34.Expression and prognostic impact of PRL-3 in lymph node metastasis of gastric cancer: Its molecular mechanism was investigated using artificial microRNA interference. Int .J. ancer. 2008; 123,1439-1447 .

35.High Expression of PRL-3 can Promote Growth of Gastric Cancer and Exhibits a Poor Prognostic Impact on Patients. Ann Surg Oncol. 2009. 16(1): 208-19.

36.Spleen preservation in radical surgery for Gastric cardiac cancer. Ann Surg Oncolog, 2007; 14(4): 1312-1319

37.Is Albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?:A prospective randomized controlled trial. Am J Surg. 2008 Nov;196(5):751-5.

38.Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model. Chin Med J (Engl). 2008 Nov 5;121(21):2167-71

 

专著：

1.主编《胃癌淋巴转移》人民卫生出版社 2011.4。

2. 主编《直肠癌保肛手术》人民卫生出版社 2009.2。

3. 副主编《普通外科疾病临床诊断与治疗方案》科学技术文献出版社 2012.5。

4. 副主编《胃癌外科学》人民卫生出版社 2014.4。

5.主译《消化道肿瘤诊断与治疗》人民卫生出版社 2012.3。

6.参编《胃肠外科学》、《消化肿瘤外科学》、《胃肠外科手术学》、《外科学》本科教材、《外科临床手册》等著作。

 

其他主要工作成绩（比如获奖情况）：

1.“提高胃癌外科疗效的临床与基础研究”分别获得2005年度中华医学会医学科技进步二等奖和广东省科技进步二等奖；

2.“直肠癌保功能手术”获得2006年度广东省科技进步一等奖；

3.“进展期胃癌外科治疗及应用基础研究”分获2010年度中华医学奖三等奖和广东省科技二等奖。